| Title | Role | Award | Year | |
|---|---|---|---|---|
| Milk | Actor | BAFTA Award for Best Actor in a Leading Role | 2008 | shortlisted |
| Milk | Actor | Academy Award for Best Actor | 2008 | winner |
| Milk | Actor | Golden Globe Award for Best Actor in a Motion Picture – Drama | 2008 | shortlisted |
| 21 Grams | Actor | BAFTA Award for Best Actor in a Leading Role | 2003 | shortlisted |
| Mystic River | Actor | Academy Award for Best Actor | 2003 | winner |
| Mystic River | Actor | Golden Globe Award for Best Actor in a Motion Picture – Drama | 2003 | winner |
| Mystic River | Actor | BAFTA Award for Best Actor in a Leading Role | 2003 | shortlisted |
| I Am Sam | Actor | Academy Award for Best Actor | 2001 | shortlisted |
| Sweet and Lowdown | Actor | Academy Award for Best Actor | 1999 | shortlisted |
| Dead Man Walking | Actor | Golden Globe Award for Best Actor in a Motion Picture – Drama | 1995 | shortlisted |
| Dead Man Walking | Actor | Academy Award for Best Actor | 1995 | shortlisted |