| Award | Nominee | Season | |
|---|---|---|---|
| Golden Globe Award for Best Television Series - Drama (2000) | - | shortlisted | |
| Golden Globe Award for Best Actress – Television Series Drama (2001) | Marg Helgenberger | - | shortlisted |
| Golden Globe Award for Best Television Series - Drama (2001) | - | shortlisted | |
| Primetime Emmy Award for Outstanding Lead Actress in a Drama Series (2001) | Marg Helgenberger | - | shortlisted |
| Golden Globe Award for Best Actress – Television Series Drama (2002) | Marg Helgenberger | - | shortlisted |
| Primetime Emmy Award for Outstanding Drama Series (2002) | Season 2 | shortlisted | |
| Golden Globe Award for Best Actor – Television Series Drama (2003) | William Petersen | - | shortlisted |
| Golden Globe Award for Best Television Series - Drama (2003) | - | shortlisted | |
| Primetime Emmy Award for Outstanding Drama Series (2003) | Season 3 | shortlisted | |
| Primetime Emmy Award for Outstanding Lead Actress in a Drama Series (2003) | Marg Helgenberger | - | shortlisted |
| Primetime Emmy Award for Outstanding Drama Series (2004) | Season 4 | shortlisted |