| Award | Nominee | Season | |
|---|---|---|---|
| Golden Globe Award for Best Actor – Television Series Drama (2005) | Patrick Dempsey | - | shortlisted |
| Golden Globe Award for Best Television Series - Drama (2005) | - | shortlisted | |
| Golden Globe Award for Best Actor – Television Series Drama (2006) | Patrick Dempsey | - | shortlisted |
| Golden Globe Award for Best Actress – Television Series Drama (2006) | Ellen Pompeo | - | shortlisted |
| Golden Globe Award for Best Television Series - Drama (2006) | - | winner | |
| Primetime Emmy Award for Outstanding Drama Series (2006) | Season 2 | shortlisted | |
| Golden Globe Award for Best Television Series - Drama (2007) | - | shortlisted | |
| Primetime Emmy Award for Outstanding Drama Series (2007) | Season 3 | shortlisted |