| Award | Nominee | Season | |
|---|---|---|---|
| Golden Globe Award for Best Television Series - Drama (2004) | - | shortlisted | |
| Golden Globe Award for Best Actor – Television Series Drama (2005) | Matthew Fox | - | shortlisted |
| Golden Globe Award for Best Television Series - Drama (2005) | - | winner | |
| Primetime Emmy Award for Outstanding Drama Series (2005) | Season 1 | winner | |
| Golden Globe Award for Best Actress – Television Series Drama (2006) | Evangeline Lilly | - | shortlisted |
| Golden Globe Award for Best Television Series - Drama (2006) | - | shortlisted | |
| BAFTA Award for Best International Programme (2007) | - | shortlisted | |
| Primetime Emmy Award for Outstanding Drama Series (2008) | Season 4 | shortlisted | |
| Primetime Emmy Award for Outstanding Drama Series (2009) | Season 5 | shortlisted | |
| Primetime Emmy Award for Outstanding Drama Series (2010) | Season 6 | shortlisted | |
| Primetime Emmy Award for Outstanding Lead Actor in a Drama Series (2010) | Matthew Fox | - | shortlisted |